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Emerging options in the treatment of bipolar disorders
journal contribution
posted on 2001-08-01, 00:00 authored by Michael BerkMichael Berk, J Segal, L Janet, M VorsterBipolar disorder is a common and severe condition, and has a clinical outcome that is frequently sub-optimal. Only a small number of therapeutic options are currently available for the disorder. A growing range of novel therapeutic options for the treatment of bipolar disorder are under investigation. These include the anticonvulsants, atypical antipsychotics and options such as the omega-3 fatty acids and transcranial magnetic stimulation. Of the anticonvulsants, lamotrigine is currently the agent for which the greatest amount of controlled clinical data is accumulating, particularly in the depressed and rapid cycling phases of the illness. Olanzapine is currently the atypical antipsychotic with the largest body of evidence in mania, although data is emerging on other atypical antipsychotics including risperidone and ziprasidone. Data regarding the atypical agents in other phases of the illness are awaited. The options available for this difficult to treat condition is increasing with the new range of agents.
History
Journal
DrugsVolume
61Issue
10Pagination
1407 - 1414Publisher
SpringerLocation
Berlin, GermanyPublisher DOI
ISSN
0012-6667Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
[2001, Springer]Usage metrics
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Categories
Keywords
AnticonvulsantsAntipsychotic AgentsBipolar DisorderClinical Trials as TopicElectric Stimulation TherapyElectroconvulsive TherapyFatty Acids, Omega-3HumansMagneticsPrognosisSkullScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyToxicologyTRANSCRANIAL MAGNETIC STIMULATIONRANDOMIZED CONTROLLED TRIALRAPID CYCLING PATIENTSDOUBLE-BLINDACUTE MANIACLINICAL-EXPERIENCEMOOD DISORDERSOPEN-LABELELECTROCONVULSIVE-THERAPYSCHIZOAFFECTIVE DISORDER