liu-encapsulationofhydr-2014.pdf (929.33 kB)
Encapsulation of hydrophobic phthalocyanine with poly(N-isopropylacrylamide)/lipid composite microspheres for thermo-responsive release and photodynamic therapy
journal contribution
posted on 2014-01-01, 00:00 authored by J Liu, Jingliang LiJingliang Li, Z Zhang, Y Weng, G Chen, B Yuan, K Yang, Y MaPhthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., Pc@pNIPAM or Pc@pNIPAM/lipid), to improve its water solubility and prevent aggregation in aqueous medium. The incorporation of lipid molecules significantly enhances the Pc loading efficiency of pNIPAM. These Pc@pNIPAM and Pc@pNIPAM/lipid composite microspheres show thermo-triggered release of Pc and/or lipid due to the phase transition of pNIPAM. Furthermore, in the in vitro experiments, these composite particles work as drug carriers for the hydrophobic Pc to be internalized into HeLa cells. After internalization, the particles show efficient fluorescent imaging and PDT effect. Our work demonstrates promising candidates in promoting the use of hydrophobic drugs including photosensitizers in tumor therapies. © 2014 by the authors.
History
Journal
MaterialsVolume
7Issue
5Pagination
3481 - 3493Publisher
MDPI AGLocation
Basel, SwitzerlandPublisher DOI
eISSN
1996-1944Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
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Composite microsphereControlled releasePhospholipidPhotodynamic therapyPhthalocyanineScience & TechnologyPhysical SciencesTechnologyChemistry, PhysicalMaterials Science, MultidisciplinaryMetallurgy & Metallurgical EngineeringPhysics, AppliedPhysics, Condensed MatterChemistryMaterials SciencePhysicsHOLLOW SILICA NANOPARTICLESIN-VIVOZINC PHTHALOCYANINESPNIPAM MICROGELSDRUG-DELIVERYPARTICLESCANCERDENDRIMERPHOTOSENSITIZERSINTERNALIZATION
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