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Encapsulation of solid dispersion in solid lipid particles for dissolution enhancement of poorly water-soluble drug

Version 2 2024-06-06, 10:23
Version 1 2017-07-24, 09:27
journal contribution
posted on 2024-06-06, 10:23 authored by KTM Tran, T Van Vo, BJ Lee, Wei DuanWei Duan, PHL Tran, TTD Tran
Background: The aim of this research was to engineer solid dispersion lipid particles (SDSLs) in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs), thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug. Methods: Ultrasonication was introduced into the process to obtain micro/nanoscale SLs. The mechanism of dissolution enhancement was investigated by analysing the crystalline structure, molecular interactions, and particle size of the formulations. Results: The drug release from the SD-SLs was significantly greater than that from the SD or SLs alone. This enhancement in drug release was dependent on the preparation method and the drug-topolymer ratio of the SD. With an appropriate amount of polymer in the SD, the solidification method had the potential to alter the drug crystallinity to an amorphous state, resulting in particle uniformity and molecular interactions in the SD-SLs. Conclusions: The proposed system provides a new strategy for enhancing the dissolution rate of poorly water-soluble drugs and further improving their bioavailability.

History

Journal

Current Drug Delivery

Volume

15

Pagination

576-584

Location

United Arab Emirates

ISSN

1567-2018

eISSN

1875-5704

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

[2018, Bentham Science Publishers]

Issue

4

Publisher

BENTHAM SCIENCE PUBL LTD