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Enhanced peroxidase-like properties of graphene-hemin-composite decorated with Au nanoflowers as electrochemical aptamer biosensor for the detection of K562 leukemia cancer cells

journal contribution
posted on 2016-12-12, 00:00 authored by Jing Liu, Meirong Cui, Li Niu, Hong Zhou, Shusheng Zhang
Graphene composites with hemin and gold nanoparticles show a better performance for hydrogen peroxide decomposition compared to that of the three components alone or duplex/hybrid complexes. Our previous studies showed that the morphology of the Au nanoparticles may greatly influence the catalytic activity of graphene-family peroxidase mimics. Recently, we found that Au nanoflowers could grow in situ and form on the surface of hemin/RGO (reduced graphene oxide). The prickly morphology of this Au nanoflower brought a higher catalytic ability with enhanced kinetic parameters than traditional Au nanoparticles that showed a smooth surface. Therefore, based on this discovery, a smart electrochemical aptamer biosensor for K562 leukemia cancer cells was further presented with good performance in selectivity and sensitivity attributed to the excellent mimetic peroxidase catalytic activity of this newly synthesized Au nanoflower decorated graphene-hemin composite (H-RGO-Au NFs).

History

Journal

Chemistry

Volume

22

Pagination

18001-18008

Location

Weinheim, Germany

eISSN

1521-3765

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2016, Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

Issue

50

Publisher

Wiley

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