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Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
journal contribution
posted on 2022-11-23, 04:28 authored by P Paschou, Y Jin, K Müller-Vahl, HE Möller, R Rizzo, PJ Hoekstra, V Roessner, N Mol Debes, Y Worbe, A Hartmann, P Mir, D Cath, I Neuner, H Eichele, C Zhang, K Lewandowska, A Munchau, J Verrel, R Musil, Tim SilkTim Silk, CA Hanlon, ED Bihun, V Brandt, A Dietrich, N Forde, C Ganos, DJ Greene, C Chu, MJ Grothe, T Hershey, P Janik, JM Koller, JF Martin-Rodriguez, K Müller, S Palmucci, A Prato, S Ramkiran, F Saia, N Szejko, R Torrecuso, Z Tumer, A Uhlmann, T Veselinovic, T Wolańczyk, JJ Zouki, P Jain, A Topaloudi, M Kaka, Z Yang, P Drineas, SI Thomopoulos, T White, DJ Veltman, L Schmaal, DJ Stein, J Buitelaar, B Franke, O van den Heuvel, N Jahanshad, PM Thompson, KJ BlackTourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.
History
Journal
Frontiers in PsychiatryVolume
13Article number
958688Pagination
01-11Location
Lausanne, SwitzerlandPublisher DOI
ISSN
1664-0640eISSN
1664-0640Language
EnglishPublication classification
C1 Refereed article in a scholarly journalPublisher
Frontiers MediaUsage metrics
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Keywords
ABNORMALITIESBRAINbrain MRICOPY NUMBER VARIANTSENIGMAGENERATION RgeneticsGENOME-WIDE ASSOCIATIONHISTIDINE-DECARBOXYLASELife Sciences & BiomedicineNETWORKSneuroimagingPHENOTYPESPsychiatryRISKScience & TechnologyTIC DISORDERSTourette syndromeDepressionIntellectual and Developmental Disabilities (IDD)GeneticsBehavioral and Social ScienceMental HealthTourette SyndromeBrain DisordersPediatricAnxiety DisordersSerious Mental IllnessAutismNeurosciencesNeurodegenerative2.1 Biological and endogenous factors1.1 Normal biological development and functioningNeurologicalMental healthPublic Health and Health Services not elsewhere classifiedClinical Sciences not elsewhere classifiedPsychology not elsewhere classified
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