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Epidemiological modelling (including economic modelling) and its role in preventive drug therapy

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Version 1 2017-07-20, 15:14
journal contribution
posted on 2024-06-04, 06:19 authored by D Liew, JJ McNeil, Anna PeetersAnna Peeters, SS Lim, T Vos
In contrast to curative therapies, preventive therapies are administered to largely healthy individuals over long periods. The risk-benefit and cost-benefit ratios are more likely to be unfavourable, making treatment decisions difficult. Drug trials provide insufficient information for treatment decisions, as they are conducted on highly selected populations over short durations, estimate only relative benefits of treatment and offer little information on risks and costs. Epidemiological modelling is a method of combining evidence from observational epidemiology and clinical trials to assist in clinical and health policy decision-making. It can estimate absolute benefits, risks and costs of long-term preventive strategies, and thus allow their precise targeting to individuals for whom they are safest and most cost-effective. Epidemiological modelling also allows explicit information about risks and benefits of therapy to be presented to patients, facilitating informed decision-making.

History

Journal

Medical journal of Australia

Volume

177

Pagination

364-367

Location

Sydney, N.S.W.

Open access

  • Yes

ISSN

0025-729X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2002, Medical Journal of Australia

Issue

7

Publisher

Australasian Medical Publishing Company

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