peeters-epidemiologicalmodelling-2002.pdf (292.11 kB)
Epidemiological modelling (including economic modelling) and its role in preventive drug therapy
journal contribution
posted on 2002-10-07, 00:00 authored by D Liew, J J McNeil, Anna PeetersAnna Peeters, S S Lim, T VosIn contrast to curative therapies, preventive therapies are administered to largely healthy individuals over long periods. The risk-benefit and cost-benefit ratios are more likely to be unfavourable, making treatment decisions difficult. Drug trials provide insufficient information for treatment decisions, as they are conducted on highly selected populations over short durations, estimate only relative benefits of treatment and offer little information on risks and costs. Epidemiological modelling is a method of combining evidence from observational epidemiology and clinical trials to assist in clinical and health policy decision-making. It can estimate absolute benefits, risks and costs of long-term preventive strategies, and thus allow their precise targeting to individuals for whom they are safest and most cost-effective. Epidemiological modelling also allows explicit information about risks and benefits of therapy to be presented to patients, facilitating informed decision-making.
History
Journal
Medical journal of AustraliaVolume
177Issue
7Pagination
364 - 367Publisher
Australasian Medical Publishing CompanyLocation
Sydney, N.S.W.Link to full text
ISSN
0025-729XLanguage
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2002, Medical Journal of AustraliaUsage metrics
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No categories selectedKeywords
AustraliaCoronary DiseaseCost-Benefit AnalysisDecision Support TechniquesEpidemiologic MethodsHumansModels, EconomicRisk Assessmenteconomicsgeneral medicinestatisticsepidemiologyresearch designScience & TechnologyLife Sciences & BiomedicineMedicine, General & InternalGeneral & Internal MedicineCORONARY-HEART-DISEASECOST-EFFECTIVENESSRISKPRAVASTATINWESTMEN
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