Deakin University
Browse
craig-epigeneticage-2019.pdf (346.03 kB)

Epigenetic age acceleration in adolescence associates with BMI, inflammation, and risk score for middle age cardiovascular disease

Download (346.03 kB)
journal contribution
posted on 2019-07-01, 00:00 authored by R C Huang, K A Lillycrop, L J Beilin, K M Godfrey, D Anderson, T A Mori, S Rauschert, Jeffrey CraigJeffrey Craig, W H Oddy, O T Ayonrinde, C E Pennell, J D Holbrook, P E Melton
Accelerated aging, assessed by adult DNA methylation, predicts cardiovascular disease (CVD). Adolescent accelerated aging might predict CVD earlier. We investigated whether epigenetic age acceleration (assessed age, 17 years) was associated with adiposity/CVD risk measured (ages 17, 20, and 22 years) and projected CVD by middle age. Design: DNA methylation measured in peripheral blood provided two estimates of epigenetic age acceleration: intrinsic (IEAA; preserved across cell types) and extrinsic (EEAA; dependent on cell admixture and methylation levels within each cell type). Adiposity was assessed by anthropometry, ultrasound, and dual-energy x-ray absorptiometry (ages 17, 20, and 22 years). CVD risk factors [lipids, homeostatic model assessment of insulin resistance (HOMA-IR), blood pressure, inflammatory markers] were assessed at age 17 years. CVD development by age 47 years was calculated by Framingham algorithms. Results are presented as regression coefficients per 5-year epigenetic age acceleration (IEAA/EEAA) for adiposity, CVD risk factors, and CVD development.

History

Journal

Journal of clinical endocrinology and metabolism

Volume

104

Issue

7

Pagination

3012 - 3024

Publisher

Oxford Univesity Press

Location

Oxford, Eng.

ISSN

0021-972X

eISSN

1945-7197

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Endocrine Society

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC