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Epigenetic Influences on Neurodevelopment at 11 Years of Age: Protocol for the Longitudinal Peri/Postnatal Epigenetic Twins Study at 11 Years of Age (PETS@11)

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journal contribution
posted on 2024-06-18, 19:20 authored by P Leong, YJ Loke, R Saffery, Tim SilkTim Silk, A Burnett, E Josev, K Scurrah, C Theda, A Czajko, EPK Pua, ML Seal, Jeffrey CraigJeffrey Craig
AbstractNeurodevelopment is sensitive to genetic and pre/postnatal environmental influences. These effects are likely mediated by epigenetic factors, yet current knowledge is limited. Longitudinal twin studies can delineate the link between genetic and environmental factors, epigenetic state at birth and neurodevelopment later in childhood. Building upon our study of the Peri/postnatal Epigenetic Twin Study (PETS) from gestation to 6 years of age, here we describe the PETS 11-year follow-up in which we will use neuroimaging and cognitive testing to examine the relationship between early-life environment, epigenetics and neurocognitive outcomes in mid-childhood. Using a within-pair twin model, the primary aims are to (1) identify early-life epigenetic correlates of neurocognitive outcomes; (2) determine the developmental stability of epigenetic effects and (3) identify modifiable environmental risk factors. Secondary aims are to identify factors influencing gut microbiota between 6 and 11 years of age to investigate links between gut microbiota and neurodevelopmental outcomes in mid-childhood. Approximately 210 twin pairs will undergo an assessment at 11 years of age. This includes a direct child cognitive assessment, multimodal magnetic resonance imaging, biological sampling, anthropometric measurements and a range of questionnaires on health and development, behavior, dietary habits and sleeping patterns. Data from complementary data sources, including the National Assessment Program — Literacy and Numeracy and the Australian Early Development Census, will also be sought. Following on from our previous focus on relationships between growth, cardiovascular health and oral health, this next phase of PETS will significantly advance our understanding of the environmental interactions that shape the developing brain.

History

Journal

Twin Research and Human Genetics

Volume

22

Season

Special Issue 6: Twin family registries worldwide: An important resource for scientific research

Article number

PII S1832427419001208

Pagination

446-453

Location

England

Open access

  • Yes

ISSN

1832-4274

eISSN

1839-2628

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

6

Publisher

CAMBRIDGE UNIV PRESS