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Epigenetic regulation of skeletal muscle metabolism

journal contribution
posted on 2016-01-01, 00:00 authored by Kirsten HowlettKirsten Howlett, Sean McgeeSean Mcgee
Normal skeletal muscle metabolism is essential for whole body metabolic homoeostasis and disruptions in muscle metabolism are associated with a number of chronic diseases. Transcriptional control of metabolic enzyme expression is a major regulatory mechanism for muscle metabolic processes. Substantial evidence is emerging that highlights the importance of epigenetic mechanisms in this process. This review will examine the importance of epigenetics in the regulation of muscle metabolism, with a particular emphasis on DNA methylation and histone acetylation as epigenetic control points. The emerging cross-talk between metabolism and epigenetics in the context of health and disease will also be examined. The concept of inheritance of skeletal muscle metabolic phenotypes will be discussed, in addition to emerging epigenetic therapies that could be used to alter muscle metabolism in chronic disease states.

History

Journal

Clinical Science

Volume

130

Pagination

1051-1063

Location

England

ISSN

0143-5221

eISSN

1470-8736

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2016, The Authors

Issue

13

Publisher

PORTLAND PRESS LTD