Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

Ni, J; Cozzi, P; Hao, J; Beretov, J; Chang, L; Duan, Wei; Shigdar, Sarah; Delprado, W; Graham, P; Bucci, J; Kearsley, J; Li, Y

Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

journal contribution

posted on 2013-12-01, 00:00 authored by J Ni, P Cozzi, J Hao, J Beretov, L Chang, Wei DuanWei Duan, Sarah ShigdarSarah Shigdar, W Delprado, P Graham, J Bucci, J Kearsley, Y Li

Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

History

Journal

International journal of biochemistry and cell biology

Volume

45

Issue

12

Pagination

2736 - 2748

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

1357-2725

eISSN

1878-5875

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2013, Elsevier

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Keywords

EpCAM (CD326)prostate cancer metastasis chemoresistance radioresistance PI3K\/Akt\/mTOR Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Cell Biology CIRCULATING TUMOR-CELLS IN-VITRO PROPAGATION BREAST-CANCER STEM-CELLS STEM\/PROGENITOR CELLS EXPRESSION PATTERNS INITIATING CELLS DRUG-RESISTANCE EP-CAM IDENTIFICATION 3,3′ diaminobenzidine 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide BPH BSA CPTC CRPC CSC CTC CaP DAB DOX DTX ECL EMT EpCAM FBS HGPIN HRP KD MAb MMRD MTT PI PSA PTX PVDF RP RT SD TBS TMA Tris-buffered saline benign prostate hyperplasia bovine serum albumin cancer stem cell castration-resistant prostate cancer circulating prostate tumor cells circulating tumor cell docetaxel doxorubicin enhanced chemiluminescence epithelial cell adhesion molecule epithelial–mesenchymal transition fetal bovine serum high-grade prostatic intraepithelial neoplasia horseradish peroxide i.c.intracardiac knock down mismatch repair deficient monoclonal antibody o\/n overnight paclitaxel polyvinylidene difluoride propidium iodide prostate specific antigen qRT-PCR quantitative real time polymerase chain reaction radical prostatectomy room temperature s.c.scr scrambled siRNA small interfering RNA standard deviation subcutaneous tissue microarray

Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

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