singh-equivalentbeneficial-2013.pdf (157.19 kB)
Equivalent beneficial effects of unilateral and bilateral prefrontal cortex transcranial magnetic stimulation in a large randomized trial in treatment-resistant major depression
journal contribution
posted on 2013-10-01, 00:00 authored by P B Fitzgerald, K E Hoy, Ajeet SinghAjeet Singh, R Gunewardene, C Slack, S Ibrahim, P J Hall, Z J DaskalakisRepetitive transcranial magnetic stimulation treatment (rTMS) is an effective treatment for depression but the optimal methods of administration have yet to be determined. Recent studies have produced conflicting results as to whether unilateral rTMS is more or less effective than sequentially applied bilateral rTMS. To address this we conducted a trial comparing sequential bilateral rTMS to right-sided unilateral rTMS using a priming protocol. Patients with treatment-resistant depression (n = 179) were enrolled in a two-arm randomized controlled trial across a 4-wk time period. The primary outcome assessment was the Hamilton Depression Rating Scale. Overall, there was a substantial response rate of >50% (and a 40% remission rate); however, there were no significant differences in clinical response between the two treatment groups. rTMS was well tolerated with a very low discontinuation rate. There was no relationship between response in the current trial and previous response, or non-response, to electroconvulsive therapy. We found no significant differences in clinical response between sequential bilateral rTMS and right-sided unilateral rTMS applied with a priming protocol. The results of this study do not support superior efficacy of bilateral rTMS and instead suggest that other approaches should be explored to increase treatment efficacy.
History
Journal
International journal of neuropsychopharmacologyVolume
16Issue
9Pagination
1975 - 1984Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
ISSN
1461-1457eISSN
1469-5111Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2013, CINPUsage metrics
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No categories selectedKeywords
antidepressantdepressionprefrontal cortexremissionrepetitive transcranial magnetic stimulationresponseAdultAustraliaChi-Square DistributionDepressive Disorder, MajorDepressive Disorder, Treatment-ResistantDouble-Blind MethodFemaleHumansLinear ModelsMaleMiddle AgedPsychiatric Status Rating ScalesTime FactorsTranscranial Magnetic StimulationTreatment OutcomeScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesPharmacology & PharmacyPsychiatryNeurosciences & NeurologyLOW-FREQUENCYDOUBLE-BLINDPRIMING STIMULATIONECONOMIC BURDENEFFICACYRTMSINVENTORYMULTISITEDISORDER
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