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Escaping the immune system: How the malaria parasite makes vaccine development a challenge
journal contribution
posted on 2013-12-01, 00:00 authored by D I Stanisic, Alyssa BarryAlyssa Barry, M F GoodMalaria is a major cause of morbidity and mortality. Immunity is acquired but is suboptimal, being slow to develop and incomplete. An inadequate understanding of natural immunity, host-parasite interactions, and a lack of reliable immune correlates of protection that could predict vaccine efficacy in the field have hindered development of a vaccine. With data from Phase III trials indicating that the leading malaria vaccine candidate, RTS,S, has limited efficacy, it is necessary to reconsider approaches to the development of a vaccine capable of inducing long-lived protection. © 2013 Elsevier Ltd.
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Journal
Trends in ParasitologyVolume
29Issue
12Pagination
612 - 622Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1471-4922eISSN
1471-5007Language
engPublication classification
E1.1 Full written paper - refereedUsage metrics
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