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Escitalopram efficacy in depression a cross-ethnicity examination of the serotonin transporter promoter polymorphism
journal contributionposted on 2014-10-01, 00:00 authored by C Bousman, J Sarris, E S Won, H S Chang, Ajeet SinghAjeet Singh, H Y Lee, B J Ham, C H Tan, M S Lee, C Ng
Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.