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Essential oil and leaves from lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway

Version 2 2024-06-06, 08:24
Version 1 2022-11-23, 23:42
journal contribution
posted on 2024-06-06, 08:24 authored by A Sajid, Q Manzoor, M Imran, F Aslam, TA Gondal, RS Ahmad, MU Arshad, A Imran, G Hussain
The anticancer and anti-inflammatory activities of wild-sage (Lantana camara) leaves essential oil were evaluated against various human cell lines. In this regard, steam hydro-distillation technique was used for oil extraction. Chemical characterization of L. camara essential oil (LCEO) was done by GC-MS, and forty one chemical components (98.69%) were detected in leaves of LCEO. The major constituents were caryophyllene oxide (19.63%), caryophyllene (6.68%), β-phellandrene (6.48%), humulene epoxide II (5.68%), spathulenol (4.17%), α-pinene (3.27%), eucalyptol (3.09%), α-cyclocitral (2.89%), β-pinene (2.38%), and nerolidol II (2.33%). Moreover, the antioxidant and antimicrobial potential of LCEO were also examined. LCEO also showed good anti-inflammatory activity. Interestingly, it was found that the L. camara essential oil was active against a set of microbial strains along with promising antioxidant activity. The MTT assay showed that LCEO possessed good anticancer potential against U-266, A-549, HCT-116, SCC-4, MiaPaCa 2, and KBM-5 cancer cell lines. In these cell lines, it was depicted that the LCEO blocked the tumor cell proliferation via NF-κB pathway suppression. The promising and potent bioactivities of LCEO support the candidature of these essential oils as an anticancer agent

History

Journal

Sains Malaysiana

Volume

50

Pagination

2923-2936

Location

UKM Press

ISSN

0126-6039

eISSN

2735-0118

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

10

Publisher

Penerbit Universiti Kebangsaan Malaysia