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Evaluation of a dry powder delivery system for laninamivir in a ferret model of influenza infection

journal contribution
posted on 2015-08-01, 00:00 authored by J Panozzo, D Y Oh, K Margo, David MortonDavid Morton, D Piedrafita, J Mosse, A C Hurt
Laninamivir is a long-acting antiviral requiring only a single dose for the treatment of influenza infection, making it an attractive alternative to existing neuraminidase inhibitors that require multiple doses over many days. Like zanamivir, laninamivir is administered to patients by inhalation of dry powder. To date, studies investigating the effectiveness of laninamivir or zanamivir in a ferret model of influenza infection have administered the drug in a solubilised form. To better mimic the delivery action of laninamivir in humans, we assessed the applicability of a Dry Powder Insufflator™ (DPI) as a delivery method for laninamivir octanoate (LO) in ferrets to determine the effectiveness of this drug in reducing influenza A and B virus infections. In vitro characterisation of the DPI showed that both the small particle sized LO (0.7-6.0 μm diameter) and the large particle sized lactose carrier (20-100 μm diameter) were effectively discharged. However, LO delivered to ferrets via the DPI prior to infection with either A(H1N1)pdm09 or B viruses had a limited effect on nasal inflammation, clinical symptoms and viral shedding compared to placebo. Our preliminary findings indicate the feasibility of administering powder drugs into ferrets, but a better understanding of the pharmacokinetics and pharmacodynamics of LO in ferrets following delivery by the DPI is warranted prior to further studies.

History

Journal

Antiviral Research

Volume

120

Pagination

66 - 71

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0166-3542

eISSN

1872-9096

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2015, Elsevier