austin-evaluationof-2013.pdf (123.78 kB)
Evaluation of biogenic amines in the faeces of children with and without autism by LC-MS/MS
journal contribution
posted on 2013-01-01, 00:00 authored by S Gondalia, P Mahon, E Palombo, S Knowles, David AustinDavid AustinPrevious researchers have postulated that gastrointestinal bacteria may contribute to the development and maintenance of Autism Spectrum Disorders (ASD). There is evidence based on quantitative evaluation of the gastrointestinal bacterial population in ASD that this is unlikely and an alternate mechanism will be examined where the bacteria may contribute to the development of ASD via their metabolic products and the role of biogenic amines (BAs) will be investigated. In humans, BAs influence a number of physiological processes via their actions as neurotransmitters, local hormones and gastric acid secretion. Various amines have been implicated in several medical conditions such as schizophrenia and colon cancer. To date, the relationship between BAs and autism has not been explored. This study has been designed to identify differences (and/or similarities) in the level of Bas in faecal samples of autistic children (without gastrointestinal dysfunction: n = 14; with gastrointestinal dysfunction; n = 21) and their neurotypical siblings (n = 35) by LC-MS/MS. Regardless of the diagnosis, severity of ASD and gastrointestinal dysfunction there were no significant differences found between the groups. The findings suggest that BAs in the gastrointestinal tract do not play a role in the pathophysiology of gastrointestinal dysfunction associated with ASD.
History
Journal
International Journal of Biotechnology and BiochemistryVolume
9Issue
2Pagination
245 - 255Publisher
Research India PublicationsLocation
Delhi, IndiaISSN
0973-2691eISSN
0974-4762Language
engPublication classification
C1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2013, Research India PublicationsUsage metrics
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