Deakin University
Browse
suleria-evaluationofthe-2018.pdf (853.47 kB)

Evaluation of the spermatogenic activity of polyherbal formulation in oligospermic males

Download (853.47 kB)
journal contribution
posted on 2018-07-25, 00:00 authored by Syed Ammar Hussain, Ahsan Hameed, Furqan Nasir, Yang Wu, Hafiz SuleriaHafiz Suleria, Yuanda Song
The therapeutic use of natural herbs is an ancient human civilization act and the numbers of people have reliance on their pharmacological properties and preferred to use the natural herbs. People also use to consume these herbs as supplements to energize, bolster, and eventually enhance sexual ability. Polyherbal formulation (PHF) is one of these herbal amalgams that can be used to treat sexual dysfunction including erectile dysfunction, impotence, ejaculation dysfunction, and hypogonadism. The pilot study was aimed at evaluating the capacity of PHF in enhancing the spermatogenic potential of oligospermic patients. Thirty-six male patients with oligospermia were enrolled and randomized either to treatment (n = 23) with PHF (750 mg/d in three doses for 90 days) or to placebo (n = 13) in the same protocol. The preintervention semen analysis was compared with posttreatment semen analysis. Based on the postintervention semen analysis, patients were advised to undergo either in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to assess their fertility status. After polyherbal treatment, there was a 256% increase in sperm concentration (9.59 ± 4.37 × 106/mL to 25.61 ± 8.6 × 106/mL; P ≤0.001), 154% increase in semen volume (1.7 ± 0.14 mL to 4.32 ± 0.38 mL; P ≤0.001), and 215% increase in sperm motility (15.43 ± 2.40% to 48.65 ± 5.10%; P ≤ 0.001) on day 90 from baseline. Furthermore, a significant improvement and regulation were also observed in serum hormone levels with PHF treatment as compared to the placebo group. The present study demonstrated the evidence on synergistic spermatogenic effect of PHF as attributed in ayurveda for the treatment of oligospermia leading to infertility.

History

Journal

BioMed research international

Volume

2018

Article number

2070895

Pagination

1 - 10

Publisher

Hindawi Publishing Corporation

Location

Cairo, Egypt

ISSN

2314-6133

eISSN

2314-6141

Language

eng

Publication classification

C1 Refereed article in a scholarly journal; C Journal article

Copyright notice

2018, Syed Ammar Hussain et al.

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC