Evolution of nonbasic thienopyrimidinone containing alcohols as selective MCHR1 antagonists culminating in the discovery of the clinical candidate BMS-830216

Washburn, William N; Manfredi, Mark; Devasthale, Pratik; Zhao, Guohua; Ahmad, Saleem; Hernandez, Andres; Robl, Jeffrey A; Wang, Wei; Mignone, James; Wang, Zhenghua; Ngu, Khehyong; Pelleymounter, Mary Ann; Longhi, Daniel; Huang, Ning; Flynn, Neil; Azzara, Anthony V; Barrish, Joel C; Rohrbach, Kenneth; Devenny, James; Rooney, Suzanne; Thomas, Michael; Glick, Susan; Godonis, Helen; Harvey, Susan; Cullen, Mary Jane; Taylor, Simeon; Zhang, Hongwei; Caporuscio, Christian; Stetsko, Paul; Grubb, Mary; Maxwell, Brad D; Yang, Hong; Apedo, Atsu; Gemzik, Brian; Janovitch, Evan; Huang, Christine; Zhang, Lisa; Freeden, Chris; Murphy, Brian J

Evolution of nonbasic thienopyrimidinone containing alcohols as selective MCHR1 antagonists culminating in the discovery of the clinical candidate BMS-830216

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posted on 2024-04-08, 05:21 authored by William N Washburn, Mark Manfredi, Pratik Devasthale, Guohua Zhao, Saleem Ahmad, Andres Hernandez, Jeffrey A Robl, Wei Wang, James Mignone, Zhenghua Wang, Khehyong Ngu, Mary Ann Pelleymounter, Daniel Longhi, Ning Huang, Neil Flynn, Anthony V Azzara, Joel C Barrish, Kenneth Rohrbach, James Devenny, Suzanne Rooney, Michael Thomas, Susan Glick, Helen Godonis, Susan Harvey, Mary Jane Cullen, Simeon TaylorSimeon Taylor, Hongwei Zhang, Christian Caporuscio, Paul Stetsko, Mary Grubb, Brad D Maxwell, Hong Yang, Atsu Apedo, Brian Gemzik, Evan Janovitch, Christine Huang, Lisa Zhang, Chris Freeden, Brian J Murphy

Evolution of nonbasic thienopyrimidinone containing alcohols as selective MCHR1 antagonists culminating in the discovery of the clinical candidate BMS-830216

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ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Volume

244

Location

PA, Philadelphia

ISSN

0065-7727

Language

English

Publication classification

E3.1 Extract of paper

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AMER CHEMICAL SOC

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Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry

Evolution of nonbasic thienopyrimidinone containing alcohols as selective MCHR1 antagonists culminating in the discovery of the clinical candidate BMS-830216

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