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Examination of Cerebellar Grey-Matter Volume in Children with Neurodevelopmental Disorders: a Coordinated Analysis Using the ACAPULCO Algorithm
journal contributionposted on 2023-02-15, 04:33 authored by L Fernandez, Alex BurmesterAlex Burmester, JD Duque, Tim SilkTim Silk, Christian HydeChristian Hyde, Melissa KirkovskiMelissa Kirkovski, Peter EnticottPeter Enticott, Karen CaeyenberghsKaren Caeyenberghs
Alterations in cerebellar morphology relative to controls have been identified in children with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and developmental coordination disorder (DCD). However, it is not clear if common cerebellar regions are affected in each neurodevelopmental disorder and whether cerebellar morphological changes reflect a generic developmental vulnerability, or disorder-specific characteristic. The present study concatenated anatomical MRI scans from five existing cohorts, resulting in data from 252 children between the age of 7 and 12 years (ASD = 58, ADHD = 86, DCD = 22, Controls = 86). The ACAPULCO processing pipeline for cerebellar segmentation was conducted on T1-weighted images. A voxel-wise approach with general linear model was used to compare grey-matter volume of the 27 cerebellar lobules between each clinical group and controls. Our findings revealed that the ADHD group showed lower grey-matter volume in the left Crus I – part of the executive/non-motor portion of the cerebellum, relative to controls (p = 0.02). This no longer remained significant after controlling for medication status. There were no regions of significant differences in volume of the cerebellar lobules in ASD or DCD compared to controls. Future work will conduct harmonisation of behavioural data (cognitive and motor outcomes) across cohorts, enabling more advanced analyses to identify symptom cluster across neurodevelopmental disorders.
Publication classificationC1 Refereed article in a scholarly journal
Science & TechnologyLife Sciences & BiomedicineNeurosciencesNeurosciences & NeurologyCerebellumNeurodevelopmental disordersADHDASDDCDNeuroimagingAUTISMAttention Deficit Disorder (ADD)Clinical ResearchBiomedical ImagingBehavioral and Social SciencePediatricIntellectual and Developmental Disabilities (IDD)Mental HealthBrain DisordersAutism2 Aetiology2.1 Biological and endogenous factorsMental healthCognitive Sciences