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Examining resting-state functional connectivity in key hubs of the default mode network in chronic low back pain

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journal contribution
posted on 01.10.2021, 00:00 authored by S K Ng, D M Urquhart, P B Fitzgerald, F M Cicuttini, Melissa KirkovskiMelissa Kirkovski, J J Maller, Peter EnticottPeter Enticott, S L Rossell, B M Fitzgibbon
Abstract

Objectives
Changes in brain connectivity have been observed within the default mode network (DMN) in chronic low back pain (CLBP), however the extent of these disruptions and how they may be related to CLBP requires further examination. While studies using seed-based analysis have found disrupted functional connectivity in the medial prefrontal cortex (mPFC), a major hub of the DMN, limited studies have investigated other equally important hubs, such as the posterior cingulate cortex (PCC) in CLBP.


Methods
This preliminary study comprised 12 individuals with CLBP and 12 healthy controls who completed a resting-state functional magnetic resonance imaging (fMRI) scan. The mPFC and PCC were used as seeds to assess functional connectivity.


Results
Both groups displayed similar patterns of DMN connectivity, however group comparisons showed that CLBP group had reduced connectivity between the PCC and angular gyrus compared to healthy controls. An exploratory analysis examined whether the alterations observed in mPFC and PCC connectivity were related to pain catastrophizing in CLBP, but no significant associations were observed.


Conclusions
These results may suggest alterations in the PCC are apparent in CLBP, however, the impact and functional role of these disruptions require further investigation.

History

Journal

Scandinavian Journal of Pain

Volume

21

Issue

4

Pagination

839 - 846

Publisher

WALTER DE GRUYTER GMBH

Location

Germany

ISSN

1877-8860

eISSN

1877-8879

Language

English

Publication classification

C1 Refereed article in a scholarly journal