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Exercise and GLUT4
journal contribution
posted on 2020-07-01, 00:00 authored by M Flores-Opazo, Sean McgeeSean Mcgee, M HargreavesThe glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.
History
Journal
Exercise and sport sciences reviewsVolume
48Issue
3Pagination
110 - 118Publisher
Wolters KluwerLocation
Philadelphia, Pa.Publisher DOI
eISSN
1538-3008Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Keywords
exerciseGLUT4insulin sensitivityskeletal musclemuscleglucoseScience & TechnologyLife Sciences & BiomedicinePhysiologySport SciencesHUMAN SKELETAL-MUSCLESTIMULATED GLUCOSE-TRANSPORTACTIVATED PROTEIN-KINASEMYOCYTE ENHANCER FACTOR-2INSULIN ACTIONENDURANCE EXERCISEINDUCED INCREASEMESSENGER-RNANITRIC-OXIDEADIPOSE-TISSUEMechanical Engineering
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