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Exercise and MEF2–HDAC interactions.

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journal contribution
posted on 2007-10-01, 00:00 authored by Sean McgeeSean Mcgee
Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5′-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.

History

Journal

Applied physiology, nutrition and metabolism

Volume

32

Pagination

852 - 856

Location

Ottawa, Ontario

Open access

  • Yes

ISSN

1715-5312

eISSN

1715-5320

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2007, NRC Canada

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