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Exercise and glycemic control: focus on redox homeostasis and redox-sensitive protein signaling

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journal contribution
posted on 2017-05-01, 00:00 authored by Lewan ParkerLewan Parker, Chris ShawChris Shaw, N K Stepto, I Levinger
Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiometabolic disease. Paradoxically, acute exercise transiently increases oxidative stress and SAPK signaling, yet postexercise glycemic control and skeletal muscle function are enhanced. Furthermore, regular exercise leads to the upregulation of antioxidant defense, which likely assists in the mitigation of chronic oxidative stress-associated disease. In this review, we explore the complex spatiotemporal interplay between exercise, oxidative stress, and glycemic control, and highlight exercise-induced reactive oxygen species and redox-sensitive protein signaling as important regulators of glucose homeostasis.

History

Journal

Frontiers in endocrinology

Volume

8

Article number

87

Pagination

1 - 22

Publisher

Frontiers Media

Location

Lausanne, Switzerland

eISSN

1664-2392

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Parker, Shaw, Stepto and Levinger