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Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes
journal contribution
posted on 2012-08-01, 00:00 authored by S Hussey, Sean McgeeSean Mcgee, Andrew GarnhamAndrew Garnham, G McConell, Mark HargreavesThe aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at ∼55% peak power (Wmax). Skeletal muscle biopsies were obtained at baseline, immediately post and 3-h post exercise. GLUT4 mRNA expression increased (p < 0.05) to a similar extent immediately post exercise in control (∼60%) and T2D (∼66%) subjects, and remained elevated (p < 0.05) 3-h post exercise with no differences between groups. Similarly, p-AMP-activated protein kinase, p38 mitogen-activated kinase and proliferator-activated receptor gamma co-activator-alpha mRNA expression were increased (p < 0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.
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Journal
Diabetes, obesity and metabolismVolume
14Issue
8Pagination
768 - 771Publisher
Wiley - BlackwellLocation
Oxford, EnglandPublisher DOI
ISSN
1462-8902eISSN
1463-1326Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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