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Exploring the "preterm behavioral phenotype" in children born extremely preterm
journal contribution
posted on 2019-04-01, 00:00 authored by Alice C Burnett, George YoussefGeorge Youssef, Peter J Anderson, Julianne Duff, Lex W Doyle, Jeanie L Y Cheong, Victorian Infant Collaborative Study GroupOBJECTIVE: To examine whether difficulties in emotional, attention, and peer or social functioning (a proposed "preterm behavioral phenotype") co-occur within individual children born extremely preterm (EP; <28 weeks of gestation) and/or extremely low birth weight (ELBW; <1,000 g) and whether different behavioral profiles are related to cognitive and academic outcomes. METHODS: Population-based cohort of all EP/ELBW survivors born in the state of Victoria, Australia, in 2005, and contemporaneous matched controls were recruited at birth. At age 7 to 8 years, parents of 181 EP/ELBW and 185 control children rated their children's behavior on the Strengths and Difficulties Questionnaire problem scales (emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems). Latent profile analysis was used to explore patterns of behavior within individual children. RESULTS: Four behavioral profiles were identified: (1) minimal difficulties in all domains; (2) a profile consistent with the preterm behavioral phenotype; (3) elevations in all domains except peer problems; and (4) marked global elevations in all domains. Most preterm children (55%) had a profile of minimal difficulties. Relative to their risk of being in the minimal difficulties group, EP/ELBW children were overrepresented in the preterm behavioral phenotype (20% vs. 12% controls) and the globally elevated symptom groups (8% vs. 3%). Accounting for birth group and demographic variables, profiles with higher levels of behavior symptoms were associated with poorer cognitive and academic performance. CONCLUSION: Although more EP/ELBW children exhibited the proposed preterm behavioral phenotype than controls, it occurred in only 20% of EP/ELBW children. Greater behavior symptoms were associated with poorer cognitive and academic outcomes.
History
Journal
Journal of developmental and behavioral pediatricsVolume
40Issue
3Pagination
200 - 207Publisher
Lippincott, Williams & WilkinsLocation
Philadelphia, Pa.Publisher DOI
ISSN
0196-206XeISSN
1536-7312Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, Wolters Kluwer Health, Inc.Usage metrics
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