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Expression of defense genes in Drosophila evolves under a different selective regime from expression of other genes
journal contribution
posted on 2011-04-01, 00:00 authored by Marta L Wayne, Jason Pienaar, Marina Telonis-ScottMarina Telonis-Scott, Lyvie-Sara Sylvestre, Sergey V Nuzhdin, Lauren M McIntyreGenes involved in host-pathogen interactions are expected to be evolving under complex coevolutionary dynamics, including positive directional and/or frequency-dependent selection. Empirical work has largely focused on the evolution of immune genes at the level of the protein sequence. We examine components of genetic variance for transcript abundance of defense genes in Drosophila melanogaster and D. simulans using a diallel and a round robin breeding design, respectively, and infer modes of evolution from patterns of segregating genetic variation. Defense genes in D. melanogaster are overrepresented relative to nondefense genes among genes with evidence of significant additive variance for expression. Directional selection is expected to deplete additive genetic variance, whereas frequency-dependent selection is expected to maintain additive variance. However, relaxed selection (reduced or no purifying selection) is an alternative interpretation of significant additive variation. Of the three classes of defense genes, the recognition and effector classes show an excess of genes with significant additive variance; whereas signaling genes, in contrast, are overrepresented for dominance variance. Analysis of protein-coding sequences revealed no evidence for an association between additive or dominance variation in expression and directional selection. Both balancing selection driven by host-pathogen coevolution and relaxed selection for expression of uninduced defense genes are viable interpretations of these data.
History
Journal
EvolutionVolume
65Issue
4Pagination
1068 - 1078Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
eISSN
1558-5646Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2010, The Author(s)Usage metrics
Keywords
AnimalsCaliforniaComputational BiologyCrosses, GeneticDrosophilaEvolution, MolecularGene Expression ProfilingGene Expression RegulationGenes, InsectHost-Pathogen InteractionsImmunity, InnateLinear ModelsSelection, GeneticSpecies SpecificityDiallelgene expressionhost–pathogen coevolutionmicroarrayred queenrelaxed selectionScience & TechnologyLife Sciences & BiomedicineEcologyEvolutionary BiologyGenetics & HeredityEnvironmental Sciences & Ecologyhost-pathogen coevolutionFALSE DISCOVERY RATENATURAL-SELECTIONIMMUNE-SYSTEMRED-QUEENEVOLUTIONMELANOGASTERDOMINANCECOEVOLUTIONACCUMULATIONPOLYMORPHISMEvolutionary BiologyEcology
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