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Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels
journal contributionposted on 2023-02-07, 22:41 authored by JA Paynter, A Grimes, P Lockhart, Julian MercerJulian Mercer
The expression of the homologue of the Menkes disease gene (Mnk) in mice was studied using RNA blots. The highest level of expression of the 8.0 kb mRNA was found in placenta, substantial expression was noted in lung, heart, brain, testis and kidney and gut mucosa, but very low levels were found in spleen and adult liver. In fetal liver, the amount of Mnk mRNA is similar to that found in kidney, however, it declines soon after birth. Results with copper-loaded normal mice and mutant mice with genetic defects in copper transport suggested that Mnk mRNA levels are not regulated by tissue copper concentrations. © 1994.
PublisherELSEVIER SCIENCE BV
Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyBiophysicsCell BiologyCOPPER TRANSPORTMENKES DISEASEMOTTLED MOUSERNA BLOTMESSENGER-RNAWILSON DISEASE GENECANDIDATE GENETRANSPORTING ATPASEMETABOLISMENCODESMUTANTSAnimalsCopperEmbryo, MammalianGene Expression RegulationMenkes Kinky Hair SyndromeMiceMice, Inbred BALB CMice, Mutant StrainsRNA, MessengerSequence Homology, Nucleic AcidTissue DistributionGeneticsRare DiseasesLiver DiseaseOrphan DrugNeurodegenerativeDigestive DiseasesKidney Disease2 Aetiology1 Underpinning research2.1 Biological and endogenous factors1.1 Normal biological development and functioningEvolutionary BiologyMedicinal and Biomolecular Chemistry not elsewhere classifiedBiochemistry and Cell Biology not elsewhere classified