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Extinction of conditioned cues attenuates incubation of cocaine craving in adolescent and adult rats

Version 2 2024-06-05, 07:48
Version 1 2020-10-28, 08:13
journal contribution
posted on 2024-06-05, 07:48 authored by HB Madsen, IC Zbukvic, SJ Luikinga, AJ Lawrence, Jee Hyun KimJee Hyun Kim
© 2016 Elsevier Inc. Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has been observed in both animals and humans to increase over the first few weeks of abstinence and remain high over extended periods, a phenomenon known as ‘incubation of craving’. As adolescence represents a period of vulnerability to developing drug addiction, potentially due to persistent reactivity to drug associated cues, we first compared incubation of cocaine craving in adolescent and adult rats. Adolescent (P35) and adult (P70) rats were trained to lever press to obtain intravenous cocaine, with each drug delivery accompanied by a light cue that served as the conditioned stimulus (CS). Following acquisition of stable responding, rats were tested for cue-induced cocaine-seeking after either 1 or 30 days of abstinence. Additional groups of rats were also tested after 30 days of abstinence, however these rats were subjected to a cue extinction session 1 week into the abstinence period. Rats were injected with aripiprazole, a dopamine 2 receptor (D2R)-like partial agonist, or vehicle, 30 min prior to cue extinction. We found that adolescent and adult rats acquired and maintained a similar level of cocaine self-administration, and rats of both ages exhibited a higher level of cue-induced cocaine-seeking if they were tested after 30 days of abstinence compared to 1 day. Incubation of cocaine craving was significantly reduced to 1 day levels in both adults and adolescents that received cue extinction training. Administration of aripiprazole prior to cue extinction did not further reduce cue-induced drug-seeking. These results indicate that cue extinction training during abstinence may effectively reduce cue-induced relapse at a time when cue-induced drug craving is usually high.

History

Journal

Neurobiology of Learning and Memory

Volume

143

Pagination

88-93

Location

Amsterdam, The Netherlands

ISSN

1074-7427

eISSN

1095-9564

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Publisher

Elsevier

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