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Eye movements in parkinson's disease: Before and after pallidotomy
journal contribution
posted on 2000-07-01, 00:00 authored by T Blekher, E Siemers, Larry AbelLarry Abel, R D YeePURPOSE. To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS. Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of saccade tasks were used: saccade tasks for eliciting visually guided saccades and saccade tasks for eliciting internally mediated saccades (memory-guided, predictive, and anti-saccades). Latency, accuracy, peak velocity, and other parameters of saccades were evaluated. RESULTS. Internally mediated saccades were more impaired in patients with advanced PD compared with those with moderate PD. Pallidotomy did not affect visually guided saccades. After pallidotomy, the peak saccadic velocity of internally mediated saccades decreased. CONCLUSIONS. Hence, although pallidotomy has led to improvements in other motor functions, none were observed in saccadic responses. Rather, several modest decrements, below the level of clinical significance and all in internally mediated saccades, were observed.
History
Journal
Investigative Ophthalmology and Visual ScienceVolume
41Issue
8Pagination
2177 - 2183Publisher
Association for Research in Vision and OphthalmologyLocation
Rockville, Md.ISSN
0146-0404Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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