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FRA-1 as a driver of tumour heterogeneity: A nexus between oncogenes and embryonic signalling pathways in cancer
journal contribution
posted on 2023-01-31, 03:45 authored by Amardeep DhillonAmardeep Dhillon, E TulchinskyTumour heterogeneity is a major factor undermining the success of therapies targeting metastatic cancer. Two major theories are thought to explain the phenomenon of heterogeneity in cancer - clonal evolution and cell plasticity. In this review, we examine a growing body of work implicating the transcription factor FOS-related antigen 1 (FRA-1) as a central node in tumour cell plasticity networks, and discuss mechanisms regulating its activity in cancer cells. We also discuss evidence from the FRA-1 perspective supporting the notion that clonal selection and cell plasticity represent two sides of the same coin. We propose that FRA-1-overexpressing clones featuring high plasticity undergo positive selection during consecutive stages of multistep tumour progression. This model underscores a potential mechanism through which tumour cells retaining elevated levels of plasticity acquire a selective advantage over other clonal populations within a tumour.
History
Journal
OncogeneVolume
34Pagination
4421 - 4428Publisher DOI
ISSN
0950-9232eISSN
1476-5594Publication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyOncologyCell BiologyGenetics & HeredityEPITHELIAL-MESENCHYMAL TRANSITIONSQUAMOUS-CELL CARCINOMANEGATIVE FEEDBACK LOOPBREAST-CANCERTGF-BETASTEM-CELLSMIR-200 FAMILYPROTEASOMAL DEGRADATIONE-CADHERINTRANSCRIPTIONAL ACTIVATION
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