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Fabrication and biofunctionalization of selenium-polypyrrole core-shell nanoparticles for targeting and imaging of cancer cells
Selenium-polypyrrole core-shell nanoparticles are fabricated by an in-situ polymerization process and functionalized with transferrin for targeting and imaging of human cervical cancer cells. The shell thickness and chemical composition of the as-synthesized particles can be manipulated by controlling the precursor concentration. The presence of the polymer layer can greatly increase the thermal stability of the selenium nanoparticles. The presence of transferrin molecules on the surface of the core-shell nanoparticles can significantly enhance their cellular uptake. The tranferrin-conjugated core-shell nanoparticles can be potentially used for the targeting and imaging of cancer cells.
History
Journal
Journal of nanoscience and nanotechnologyVolume
8Issue
5Pagination
2488 - 2491Publisher
American ScientificLocation
Valencia, Calif.Publisher DOI
ISSN
1533-4880eISSN
1533-4899Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, American ScientificUsage metrics
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No categories selectedKeywords
Science & TechnologyPhysical SciencesTechnologyChemistry, MultidisciplinaryNanoscience & NanotechnologyMaterials Science, MultidisciplinaryPhysics, AppliedPhysics, Condensed MatterChemistryScience & Technology - Other TopicsMaterials SciencePhysicsseleniumpolypyrrolenanoparticletransferrincancer cellsTRANSFERRIN RECEPTORAMORPHOUS SELENIUMSPHERICAL COLLOIDSHELA-CELLSDELIVERYDENSITY
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