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Facile control over the supramolecular ordering of self-assembled peptide scaffolds by simultaneous assembly with a polysacharride

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journal contribution
posted on 06.07.2017, 00:00 authored by Rui Li, Mitchell Boyd-Moss, Benjamin Long, A Martel, A Parnell, A J C Dennison, Colin BarrowColin Barrow, D R Nisbet, R J Williams
Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.

History

Journal

Scientific reports

Volume

7

Issue

1

Article number

4797

Pagination

1 - 8

Publisher

Nature Publishing Group

Location

London, Eng.

eISSN

2045-2322

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, The Authors