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Download fileFat mass-and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study
journal contribution
posted on 2016-02-14, 00:00 authored by Katherine LivingstoneKatherine Livingstone, C Celis-Morales, S Navas-Carretero, R San-Cristobal, H Forster, C B O'Donovan, C Woolhead, C F M Marsaux, A L MacReady, R Fallaize, S Kolossa, L Tsirigoti, C P Lambrinou, G Moschonis, M Godlewska, A Surwiłło, C A Drevon, Y Manios, I Traczyk, E R Gibney, L Brennan, M C Walsh, J A Lovegrove, J A Martinez, W H M Saris, H Daniel, M Gibney, J C MathersAbstractThe interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AAv. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (Ptrend=0·028) and 3·1 cm greater WC (Ptrend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
History
Journal
British Journal of NutritionVolume
115Issue
3Pagination
440 - 448Publisher
CAMBRIDGE UNIV PRESSLocation
EnglandPublisher DOI
ISSN
0007-1145eISSN
1475-2662Language
EnglishPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, The AuthorsUsage metrics
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Categories
Keywords
BMIBODY-WEIGHTCONSUMPTIONDietary intakesENERGY-INTAKEFat mass- and obesity-associated geneFried foodsFTO GENEINDEXINSULIN-RESISTANCELife Sciences & BiomedicineNutrition & DieteticsRISKRS9939609Science & TechnologyVARIANTWEIGHT-LOSS DIETSEI total energy intakeFTO fat mass- and obesity-associated geneMD PREDIMED-based Mediterranean diet scorePA physical activityRCT randomised controlled trialWC waist circumferenceFood4Me studyAdipose TissueAdiposityAgedAged, 80 and overAllelesBody Mass IndexEnergy IntakeEuropean Continental Ancestry GroupFemaleFood HabitsGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansLife StyleMaleMiddle AgedObesitySurveys and QuestionnairesWaist Circumference