naughton-fattyacidmodulation-2013.pdf (1.37 MB)
Fatty acid modulation of the endocannabinoid system and the effect on food intake and metabolism
journal contribution
posted on 2013-01-01, 00:00 authored by Shaan NaughtonShaan Naughton, Michael L Mathai, Deanne H Hryciw, Andrew J McAinchEndocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) and an altered pattern of receptor expression. Consequently, this leads to an increase in orexigenic stimuli, changes in fatty acid synthesis, insulin sensitivity, and glucose utilisation, with preferential energy storage in adipose tissue. As endocannabinoids are products of dietary fats, modification of dietary intake may modulate their levels, with eicosapentaenoic and docosahexaenoic acid based endocannabinoids being able to displace arachidonic acid from cell membranes, reducing AEA and 2-AG production. Similarly, oleoyl ethanolamide, a product of oleic acid, induces satiety, decreases circulating fatty acid concentrations, increases the capacity for β -oxidation, and is capable of inhibiting the action of AEA and 2-AG in adipose tissue. Thus, understanding how dietary fats alter endocannabinoid system activity is a pertinent area of research due to public health messages promoting a shift towards plant-derived fats, which are rich sources of AEA and 2-AG precursor fatty acids, possibly encouraging excessive energy intake and weight gain.
History
Journal
International journal of endocrinologyVolume
2013Article number
361895Pagination
1 - 11Publisher
Hindawi Publishing CorporationLocation
Cairo, EgyptPublisher DOI
Link to full text
ISSN
1687-8337Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2013, Shaan S. Naughton et al.Usage metrics
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G-protein coupled receptors (GPCR)EndocannabinoidsObesityAcid-derived endocannabinoids anandamide (AEA)Science & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismACTIVATED RECEPTOR-ALPHALIPOPOLYSACCHARIDE-INDUCED EXPRESSIONCB1 CANNABINOID RECEPTORABDOMINAL ADIPOSE-TISSUEDIETARY LINOLEIC-ACIDANTROPYLORODUODENAL MOTILITYBODY-WEIGHTRAT-BRAINMOLECULAR CHARACTERIZATIONDEPENDENT MODULATION
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