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Fetal growth restriction: adaptations and consequences
journal contribution
posted on 2001-08-01, 00:00 authored by I C McMillen, M B Adams, J T Ross, C L Coulter, G Simonetta, Julie OwensJulie Owens, J S Robinson, L J EdwardsA range of pathophysiological factors can result in a perturbation or restriction of fetal growth, and the cardiovascular, neuroendocrine and metabolic adaptations of the fetus to these stimuli will depend on their nature, timing and intensity. The critical importance of these physiological adaptations for both immediate survival and long-term health outcomes has provided an impetus for experimental studies of the nature and consequences of specific fetal adaptations to a poor intrauterine environment. This review summarizes data from recent studies that have focused on the responses of the fetal cardiovascular, sympathoadrenal, hypothalamo-pituitary-adrenal and renin-angiotensin systems to experimental restriction of placental function in the sheep and discusses the consequences of these adaptations for fetal, neonatal and adult health.
History
Journal
ReproductionVolume
122Issue
2Pagination
195 - 204Publisher
BioscientificaLocation
Bradley Stok, Eng.ISSN
1470-1626Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2001, Journals of Reproduction and FertilityUsage metrics
Keywords
Adaptation, PhysiologicalAdrenal GlandsAnimalsCardiovascular SystemFemaleFetal Growth RetardationGlucocorticoidsHumansHypothalamusPituitary GlandPlacentaPregnancyRenin-Angiotensin SystemSympathetic Nervous SystemScience & TechnologyLife Sciences & BiomedicineDevelopmental BiologyReproductive Biology11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1MESSENGER-RNA LEVELSBLOOD-PRESSUREPLACENTAL RESTRICTIONSHEEP FETUSLATE-GESTATIONHEART-RATEGENE-EXPRESSIONACUTE-HYPOXIAPhysiology
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