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Fetal nutrition and cardiovascular disease in adult life
journal contribution
posted on 1993-04-10, 00:00 authored by D J Barker, P D Gluckman, K M Godfrey, J E Harding, Julie OwensJulie Owens, J S RobinsonBabies who are small at birth or during infancy have increased rates of cardiovascular disease and non-insulin-dependent diabetes as adults. Some of these babies have low birthweights, some are small in relation to the size of their placentas, some are thin at birth, and some are short at birth and fail to gain weight in infancy. This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth. The fetuses' adaptations to undernutrition are associated with changes in the concentrations of fetal and placental hormones. Persisting changes in the levels of hormone secretion, and in the sensitivity of tissues to them, may link fetal undernutrition with abnormal structure, function, and disease in adult life.
History
Journal
LancetVolume
341Issue
8850Pagination
938 - 941Publisher
The Lancet Publishing GroupLocation
London, Eng.Publisher DOI
ISSN
0140-6736Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1993, The Lancet Publishing GroupUsage metrics
Categories
No categories selectedKeywords
AdultBirth WeightBody HeightCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleFetal Growth RetardationHumansHydrocortisoneInfant Nutrition DisordersInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeInsulinInsulin ResistanceInsulin-Like Growth Factor IMaleNutrition DisordersPregnancyPregnancy ComplicationsRisk FactorsScience & TechnologyLife Sciences & BiomedicineMedicine, General & InternalGeneral & Internal MedicineGROWTH-RETARDED FETUSESPLACENTAL SIZELATE PREGNANCYUNDERNUTRITIONWEIGHTRISK
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