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First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis

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journal contribution
posted on 2025-04-11, 05:51 authored by Justine Boutry, Océane Rieu, Lena Guimard, Jordan Meliani, Aurora M Nedelcu, Sophie Tissot, Nikita Stepanskyy, Beata UjvariBeata Ujvari, Rodrigo Hamede, Antoine DujonAntoine Dujon, Jácint Tökölyi, Fréderic Thomas
While host phenotypic manipulation by parasites is a widespread phenomenon, whether tumors, which can be likened to parasite entities, can also manipulate their hosts is not known. Theory predicts that this should nevertheless be the case, especially when tumors (neoplasms) are transmissible. We explored this hypothesis in a cnidarian Hydra model system, in which spontaneous tumors can occur in the lab, and lineages in which such neoplastic cells are vertically transmitted (through host budding) have been maintained for over 15 years. Remarkably, the hydras with long-term transmissible tumors show an unexpected increase in the number of their tentacles, allowing for the possibility that these neoplastic cells can manipulate the host. By experimentally transplanting healthy as well as neoplastic tissues derived from both recent and long-term transmissible tumors, we found that only the long-term transmissible tumors were able to trigger the growth of additional tentacles. Also, supernumerary tentacles, by permitting higher foraging efficiency for the host, were associated with an increased budding rate, thereby favoring the vertical transmission of tumors. To our knowledge, this is the first evidence that, like true parasites, transmissible tumors can evolve strategies to manipulate the phenotype of their host.

History

Journal

eLife

Volume

13

Article number

RP97271

Pagination

1-13

Location

Cambridge, Eng.

Open access

  • Yes

ISSN

2050-084X

eISSN

2050-084X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Publisher

eLife Sciences Publications, Ltd