pascoe-fishoil-2014.pdf (2.39 MB)
Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment
journal contribution
posted on 2014-01-01, 00:00 authored by M C Pascoe, D W Howells, D P Crewther, N Constantinou, L M Carey, S S Rewell, Giovanni TurchiniGiovanni Turchini, Gunveen KaurGunveen Kaur, S G CrewtherIschemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFAs). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior.
History
Journal
Frontiers in NeurologyVolume
5Article number
14Pagination
1 - 15Publisher
Frontiers MediaLocation
Lausanne, SwitzerlandPublisher DOI
ISSN
1664-2295eISSN
1664-2295Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
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