Deakin University
Browse

File(s) under permanent embargo

Folate intake and ovarian cancer risk among women with endometriosis: a case-control study from the Ovarian Cancer Association Consortium

Version 2 2024-06-06, 05:52
Version 1 2023-06-07, 04:44
journal contribution
posted on 2024-06-06, 05:52 authored by Kate Gersekowski, Torukiri I Ibiebele, Jennifer A Doherty, Holly R Harris, Marc T Goodman, Kathryn L Terry, Anna H Wu, Elisa V Bandera, Bo Qin, Jue-Sheng Ong, Jonathan P Tyrer, Suzanne Dixon-SuenSuzanne Dixon-Suen, Francesmary Modugno, Harvey A Risch, Penelope M Webb
Abstract Background While folate intake has not been associated with an increased risk of ovarian cancer overall, studies of other cancer types have suggested that high folate intake may promote carcinogenesis in pre-cancerous lesions. Women with endometriosis (a potential pre-cancerous lesion) have an increased risk of developing ovarian cancer; however, whether high folate intake increases risk in this group is unknown. Methods We conducted a pooled analysis of six case-control studies from the Ovarian Cancer Association Consortium to investigate the association between folate intake and risk of ovarian cancer among women with and without self-reported endometriosis. We included 570 cases/558 controls with and 5,171/7,559 without endometriosis. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals for the association between folate intake (dietary, supplemental, total) and ovarian cancer risk. Finally, we used Mendelian randomization (MR) to evaluate our results using genetic markers as a proxy for folate status. Results Higher dietary folate intake was associated with an increased risk of ovarian cancer for women with endometriosis (OR 1.37[1.01-1.86]) but not for women without endometriosis. There was no association between supplemental folate intake and ovarian cancer risk for women with or without endometriosis. A similar pattern was seen using MR. Conclusions High dietary folate intake may be associated with an increased risk of ovarian cancer among women with endometriosis. Impact Women with endometriosis with high folate diets may be at increased risk of ovarian cancer. Further research is needed on the potential cancer-promoting effects of folate in this group.

History

Journal

Cancer Epidemiology, Biomarkers & Prevention

Pagination

EPI-23-0121-

Location

Philadelphia, Pa.

ISSN

1055-9965

eISSN

1538-7755

Language

en

Publication classification

C1 Refereed article in a scholarly journal

Publisher

American Association for Cancer Research (AACR)

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC