mcnaughton-foodpatterns-2009.pdf (456.87 kB)
Food patterns associated with blood lipids are predictive of coronary heart disease : the Whitehall II study
journal contribution
posted on 2009-08-28, 00:00 authored by Sarah McNaughtonSarah McNaughton, G Mishra, E BrunnerAnalysis of the epidemiological effects of overall dietary patterns offers an alternative approach to the investigation of the role of diet in CHD. We analysed the role of blood lipid-related dietary patterns using a two-step method to confirm the prospective association of dietary pattern with incident CHD. Analysis is based on 7314 participants of the Whitehall II study. Dietary intake was measured using a 127-item FFQ. Reduced rank regression (RRR) was used to derive dietary pattern scores using baseline serum total and HDL-cholesterol, and TAG levels as dependent variables. Cox proportional hazard regression was used to confirm the association between dietary patterns and incident CHD (n 243) over 15 years of follow-up. Increased CHD risk (hazard ratio (HR) for top quartile: 2·01 (95 % CI 1·41, 2·85) adjusted for age, sex, ethnicity and energy misreporting) was observed with a diet characterised by high consumption of white bread, fried potatoes, sugar in tea and coffee, burgers and sausages, soft drinks, and low consumption of French dressing and vegetables. The diet-CHD relationship was attenuated after adjustment for employment grade and health behaviours (HR for top quartile: 1·81; 95 % CI 1·26, 2·62), and further adjustment for blood pressure and BMI (HR for top quartile: 1·57; 95 % CI 1·08, 2·27). Dietary patterns are associated with serum lipids and predict CHD risk after adjustment for confounders. RRR identifies dietary patterns using prior knowledge and focuses on the pathways through which diet may influence disease. The present study adds to the evidence that diet is an important risk factor for CHD.
History
Journal
British journal of nutritionVolume
102Issue
4Pagination
619 - 624Publisher
Cambridge University PressLocation
[Cambridge, England]ISSN
0007-1145eISSN
1475-2662Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2009, Cambridge University PressUsage metrics
Categories
No categories selectedKeywords
lipidscardiovascular diseasebloodScience & TechnologyLife Sciences & BiomedicineNutrition & DieteticsDietary patternsCoronary heart diseaseProspective cohort studiesWhitehall II studyPROSPECTIVE WEIGHT CHANGECARDIOVASCULAR-DISEASEMETABOLIC SYNDROMEATHEROSCLEROSIS MESARISK-FACTORSMORTALITYMETAANALYSISCHOLESTEROLLIPOPROTEIN
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC