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Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig
journal contribution
posted on 1998-03-01, 00:00 authored by A Sohlström, A Katsman, K L Kind, C T Roberts, P C Owens, J S Robinson, Julie OwensJulie OwensThe effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother.
History
Journal
American journal of physiology: endocrinology and metabolismVolume
274Issue
3Pagination
E410 - E416Publisher
American Physiological SocietyLocation
Bethesda, Md.Publisher DOI
ISSN
0002-9513Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1998, American Physiological SocietyUsage metrics
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AnimalsBody CompositionEmbryonic and Fetal DevelopmentFemaleFood DeprivationGuinea PigsInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 4Insulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIPlacentationPregnancyPregnancy, AnimalWeight GainScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismPhysiologyinsulin-like growth factorsinsulin-like growth factor-binding proteinsGROWTH-FACTOR-IFACTOR-BINDING PROTEIN-3FETAL GROWTHCIRCULATING LEVELSPLACENTAL GROWTHMATERNAL WEIGHTSERUMEXPRESSIONHORMONERATS
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