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Fracture thresholds revisited : Geelong Osteoporosis Study
journal contribution
posted on 2002-07-01, 00:00 authored by Margaret Rogers, Julie PascoJulie Pasco, E Seeman, G Nicholson, K Sanders, Mark KotowiczMark KotowiczOsteoporosis, in the absence of fracture, is defined as a deficit in bone mineral density (BMD) of 2.5 SD or more below the young adult reference mean in postmenopausal Caucasian populations. BMD is a measure of fracture risk but not the sole predictor. We have assessed a combination of easily accessible measures of age, height, weight, and BMD to improve fracture risk assessment. Women with low trauma fractures and a control group were recruited from south-eastern Australia. Discriminant analysis derived multivariate equations that assessed fracture risk. Age was not in the best models at the spine and forearm sites. Weight and height contributed to the relationship for the forearm sites only. At the proximal femur, the BMD level that separates fracture cases from nonfracture cases, increases with age. These separation levels of BMD were higher than the WHO's level of osteoporosis (T-score < −2.5 SD) at ages older than 62 years. This increasing BMD threshold with age suggests that other age-related risk factors assume increasing importance among the elderly.
History
Journal
Journal of clinical epidemiologyVolume
55Issue
7Pagination
642 - 646Publisher
ElsevierLocation
New York, N.Y.Publisher DOI
ISSN
0895-4356eISSN
1878-5921Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2002, Elsevier ScienceUsage metrics
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