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Frontostriatal deficits in unipolar major depression
journal contribution
posted on 1998-11-01, 00:00 authored by Mark RogersMark Rogers, J L Bradshaw, C Pantelis, J G PhillipsRecent accounts of major depression have tended to focus on dysfunction of frontothalamic-striatal reentrant circuits as a possible source of the disorder. Evidence of frontostriatal involvement in unipolar major depression from lesion and neuropsychological studies, and functional and structural imaging studies is examined. The high incidence of depressive symptomatology following left frontal and basal ganglia lesions implicate these as possible sites of dysfunction. Neuropsychological evidence indicates similar deficits in patients with major depression, perhaps with dorsolateral prefrontal deficits most prominent. Structural imaging studies report frontal and basal ganglia (BG) abnormalities particularly in cases of late-age onset depression. Resting state functional imaging studies show deficits in dorsolateral, anterior cingulate (medial frontal), and BG structures. Activation imaging studies show less consistent evidence of dorsolateral deficit, while anterior cingulate deficit is more consistently demonstrated. Variability in findings across studies may reflect differences between subtypes of depression and differences in methodology. Possible involvement of the BG in the psychomotor retardation of depression is examined. It is concluded that, while there is evidence of frontostriatal deficit in major depression, the exact nature of such deficits is uncertain. Issues such as component vs. system dysfunction need to be addressed.
History
Journal
Brain research bulletinVolume
47Issue
4Pagination
297 - 310Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0361-9230Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1998, Elsevier ScienceUsage metrics
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No categories selectedKeywords
Clinical Trials as TopicCorpus StriatumDepressive DisorderDiagnostic ImagingFrontal LobeHumansNerve NetNeuropsychological TestsPsychomotor PerformancelesionsimagingBasal gangliapsychomotor retardationScience & TechnologyLife Sciences & BiomedicineNeurosciencesNeurosciences & NeurologyCEREBRAL BLOOD-FLOWPOSITRON EMISSION TOMOGRAPHYFRONTAL-SUBCORTICAL CIRCUITSSTRIATAL COGNITIVE DEFICITSMOVEMENT-RELATED POTENTIALSDELAYED-RESPONSE DEFICITSPARKINSONS-DISEASEMOOD DISORDERSGERIATRIC DEPRESSION
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