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Functional analysis of Plasmodium falciparum merozoite antigens : implications for erythrocyte invasion and vaccine development
journal contribution
posted on 2002-01-29, 00:00 authored by A Cowman, Debbie BaldiDebbie Baldi, M Duraisingh, J Healer, K Mills, R O'Donnell, Jennifer Thompson, T Triglia, M Wickham, B CrabbMalaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.
History
Journal
Philosophical transactions B. Biological sciencesVolume
357Issue
1417Pagination
25 - 33Publisher
Royal Society PublishingLocation
London, EnglandPublisher DOI
ISSN
0962-8436eISSN
1471-2970Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2002, The Royal SocietyUsage metrics
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No categories selectedKeywords
malariavaccine antigenstargeted gene disruptionPlasmodium falciparumproteinsScience & TechnologyLife Sciences & BiomedicineBiologyLife Sciences & Biomedicine - Other TopicsAPICAL MEMBRANE ANTIGENINHIBITORY MONOCLONAL-ANTIBODIESMALARIA PARASITE INVASIONC-TERMINAL FRAGMENTSURFACE PROTEIN-1RHOPTRY-PROTEINRECEPTOR HETEROGENEITYENDOPLASMIC-RETICULUMSEQUENCE-ANALYSISBINDING-PROTEINS
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