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Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells
journal contribution
posted on 2000-06-30, 00:00 authored by A Cowman, Debbie BaldiDebbie Baldi, J Healer, K Mills, R O'Donnell, M Reed, T Triglia, M Wickham, B CrabbPlasmodium falciparum causes the most lethal form of malaria in humans and is responsible for over two million deaths per year. The development of a vaccine against this parasite is an urgent priority and potential protein targets include those on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to transfect P. falciparum has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. In this review, we describe the use of this technology to examine the role of merozoite antigens in erythrocyte invasion and to address their potential as vaccine candidates.
History
Journal
FEBS lettersVolume
476Issue
1-2Pagination
84 - 88Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0014-5793eISSN
1873-3468Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2000, Federation of European Biochemical SocietiesUsage metrics
Keywords
malariavaccine antigentargeted gene disruptionplasmodium falciparumScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyBiophysicsCell Biologytargeted genedisruptionAPICAL MEMBRANE ANTIGENINHIBITORY MONOCLONAL-ANTIBODIESHUMAN MALARIA PARASITEC-TERMINAL FRAGMENTSURFACE PROTEIN-1RHOPTRY ANTIGENSEQUENCEERYTHROCYTESPRECURSORIMMUNITYEvolutionary Biology
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