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Functional imaging to understand biomechanics : a critical tool for the study of biology, pathology and the development of pharmacological solutions
journal contribution
posted on 2012-01-01, 00:00 authored by R Jamison, James ArmitageJames Armitage, J Carberry, M Kitchen, S Hooper, A FourasWe present four case studies of the literature discussing the effects of physical forces on biological function. While the field of biomechanics has existed for many decades, it may be considered by some a poor cousin to biochemistry and other traditional fields of medical research. In these case studies, including cardiovascular and respiratory systems, we demonstrate that, in fact, many systems historically believed to be controlled by biochemistry are dominated by biomechanics. We discuss both the previous paradigms that have advanced research in these fields and the changing paradigms that will define the progressions of these fields for decades to come. In the case of biomechanical effects of flowing blood on the endothelium, this has been well understood for decades. In the cases of platelet activation and liquid clearance from the lungs during birth, these discoveries are far more recent and perhaps not as universally accepted. While only a few specific examples are examined here, it is clear that not enough attention is paid to the possible mechanical links to biological function. The continued development of these research areas, with the inclusion of physical effects, will hopefully provide new insight into disease development, progression, diagnosis and effective therapies.
History
Journal
Current pharmaceutical biotechnologyVolume
13Issue
11Pagination
2128 - 2140Publisher
Bentham Science Publishers LtdLocation
Bussum, NetherlandsISSN
1389-2010eISSN
1873-4316Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
biomechanicsfunctional imagingfunctioncell mechanicslung mechanicsScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyPharmacology & PharmacyPOLYUNSATURATED FATTY-ACIDSENDOTHELIAL SHEAR-STRESSLUNG LIQUID CLEARANCEBLOOD-PRESSURE LATERERYTHROCYTE DEFORMABILITYWALL SHEARCORONARY ATHEROSCLEROSISDIETARY SUPPLEMENTATIONCAROTID BIFURCATIONMAJOR DETERMINANT
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