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Functionalized mesoporous silica nanoparticles with redox-responsive short-chain gatekeepers for agrochemical delivery.

journal contribution
posted on 2015-05-13, 00:00 authored by Zhifeng YiZhifeng Yi, H I Hussain, Chunfang Feng, Dequan Sun, Fenghua SheFenghua She, Jim RookesJim Rookes, David CahillDavid Cahill, Lingxue KongLingxue Kong
The controlled release of salicylic acid (SA), a key phytohormone, was mediated by using a novel decanethiol gatekeeper system grafted onto mesoporous silica nanoparticles (MSNs). The decanethiol was conjugated only to the external surfaces of the MSNs through glutathione (GSH)-cleavable disulfide linkages and the introduction of a process to assemble gatekeepers only on the outer surface so that the mesopore area can be maintained for high cargo loading. Raman and nitrogen sorption isotherm analyses confirmed the successful linkage of decanethiol to the surface of MSNs. The in vitro release of SA from decanethiol gated MSNs indicated that the release rate of SA in an environment with a certain amount of GSH was significantly higher than that without GSH. More importantly, in planta experiments showed the release of SA from decanethiol gated MSNs by GSH induced sustained expression of the plant defense gene PR-1 up to 7 days after introduction, while free SA caused an early peak in PR-1 expression which steadily decreased after 3 days. This study demonstrates the redox-responsive release of a phytohormone in vitro and also indicates the potential use of MSNs in planta as a controlled agrochemical delivery system.



ACS Applied Materials & Interfaces






9937 - 9946


American Chemical Society


United States





Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, American Chemical Society