dwyer-galactosetherapy-2015.pdf (971.34 kB)
Galactose therapy reduces proteinuria in patients with recurrent focal segmental glomerulosclerosis after kidney transplantation
journal contribution
posted on 2015-03-01, 00:00 authored by Kate Robson, Prudence Hill, David Langsford, Karen DwyerKaren Dwyer, David Goodman, Robyn LanghamPrimary focal segmental glomerulosclerosis is an important cause of end-stage kidney disease with a high rate of recurrent disease after kidney transplantation. Current therapy achieves remission in only half of patients. Recent interest has focused on the potential role of galactose in binding and inactivating the putative circulating permeability factor, supported by in vitro and clinical case report studies. Orally active and without major adverse effects, galactose has a favourable treatment profile compared with current immunosuppressive treatment options. We describe our experience using galactose therapy in two patients with recurrent focal segmental glomerulosclerosis after renal transplantation. Galactose was associated with symptomatic improvement and stabilization of graft function in one case; the other case was complicated by concurrent malignancy. In both cases, we observed a marked reduction in proteinuria with galactose treatment.
History
Journal
NephrologyVolume
20Issue
S1Pagination
13 - 16Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
Link to full text
eISSN
1440-1797Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2015, Asian Pacific Society of NephrologyUsage metrics
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No categories selectedKeywords
galactosefocal segmental glomerulosclerosispermeability factorAdministration, OralBiopsyGlomerulosclerosis, Focal SegmentalKidney TransplantationProteinuriaRecurrenceRemission InductionTime FactorsTreatment OutcomeScience & TechnologyLife Sciences & BiomedicineUrology & NephrologyNEPHROTIC SYNDROMEGLOMERULAR-PERMEABILITYREMISSIONFSGS
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