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Genetic and epigenetic sex-specific adaptations to endurance exercise

Version 2 2024-06-04, 13:36
Version 1 2019-05-17, 10:34
journal contribution
posted on 2024-06-04, 13:36 authored by S Landen, S Voisin, Jeffrey CraigJeffrey Craig, Sean McgeeSean Mcgee, Severine LamonSeverine Lamon, N Eynon
In recent years, the interest in personalised interventions such as medicine, nutrition, and exercise is rapidly rising to maximize health outcomes and ensure the most appropriate treatments. Exercising regularly is recommended for both healthy and diseased populations to improve health. However, there are sex-specific adaptations to exercise that often are not taken into consideration. While endurance exercise training alters the human skeletal muscle epigenome and subsequent gene expression, it is still unknown whether it does so differently in men and women, potentially leading to sex-specific physiological adaptations. Elucidating sex differences in genetics, epigenetics, gene regulation and expression in response to exercise will have great health implications, as it may enable gene targets in future clinical interventions and may better individualised interventions. This review will cover this topic and highlight the recent findings of sex-specific genetic, epigenetic, and gene expression studies, address the gaps in the field, and offer recommendations for future research.

History

Journal

Epigenetics

Volume

14

Pagination

523-535

Location

United States

Open access

  • Yes

ISSN

1559-2294

eISSN

1559-2308

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Informa UK Limited, trading as Taylor & Francis Group

Issue

6

Publisher

TAYLOR & FRANCIS INC