sharp-genomeanalysisofplatypus-2008.pdf (529.64 kB)
Genome analysis of the platypus reveals unique signatures of evolution
journal contribution
posted on 2008-05-08, 00:00 authored by Julie SharpJulie Sharp, Kevin Nicholas, W C Warren, L W Hillier, J A Marshall Graves, E Birney, C P Ponting, F Grützner, K Belov, W Miller, L Clarke, A T Chinwalla, S-P Yang, A Heger, D P Locke, P Miethke, P D Waters, F Veyrunes, L Fulton, B FultonWe present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.
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Journal
NatureVolume
453Pagination
175 - 183Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
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eISSN
1476-4687Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, Nature Publishing GroupUsage metrics
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AnimalsBase CompositionDentitionEvolution, MolecularFemaleGenomeGenomic ImprintingHumansImmunityMaleMammalsMicroRNAsMilk ProteinsPhylogenyPlatypusReceptors, OdorantRepetitive Sequences, Nucleic AcidReptilesSequence Analysis, DNASpermatozoaVenomsZona PellucidaScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsMONODELPHIS-DOMESTICAPHYLOGENETIC ANALYSISMONOTREMECHROMOSOMESINSIGHTSFAMILYELECTRORECEPTIONCATHELICIDINSARRANGEMENTEXPRESSION
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